Dexamethasone Implant, Given at 6-Month Intervals, Sustained Improvement for 3 Years
The dexamethasone intravitreal implant (Ozurdex, Allergan) produced sustained retinal structural improvement in patients with diabetic macular edema (DME) when administered in doses of 0.7 mg or 0.35 mg at 6-month intervals, according to a study published in the British Journal of Ophthalmology.1
Researchers analyzed data from two multicenter, masked, phase 3 studies with identical protocols. Patients in those studies were randomly assigned to receive treatment with the dexamethasone intravitreal implant 0.7 mg or 0.35 mg or sham. Entry criteria included DME diagnosis, BCVA of 34 to 68 ETDRS letters, and central subfield retinal thickness of at least 300 µm. Patients were followed for 3 years and treated at intervals of at least 6 months.
After 3 years, eyes in the treatment group showed mean improvement in macular edema grade compared with eyes in the sham group (P < .05). Eyes in the 0.7-mg group showed mean delayed time to onset of two-step progression in diabetic retinopathy severity by approximately 12 months.
1. Danis RP, Sadda S, Li XY, et al. Anatomical effects of dexamethasone intravitreal implant in diabetic macular oedema: a pooled analysis of 3-year phase III trials [published online ahead of print November 18, 2015]. Br J Ophthalmol.