Ocular Oncology

Winning the Battle for Life, Eye, and Vision

The field has evolved substantially to offer treatments for uveal melanoma beyond enucleation, but we still have far to go in preserving vision.

Antonio Bechara Ghobril, MD, FEBOophth, FMH; Salaam Botros, MBBS; and Carol L. Shields, MD

PVRL: When “Uveitis” Is Not Uveitis

A steroid-responsive, uveitis-presenting phenotype was ultimately diagnosed as primary vitreoretinal lymphoma.

Andreas Theocharis, MD; Romy Bejjani, MD; and Erin E. Flynn, MD

Choroidal Metastasis From Lung Adenocarcinoma

Diagnosis of choroidal malignancy should prompt a workup for systemic disease in patients with no known history of cancer.

Weilin Song, MD; Julie K. Kwon, MD; Basil K. Williams Jr, MD; and Jayanth Sridhar, MD

Reducing Chemotherapy Duration for High-Risk Retinoblastoma

Three cycles may offer comparable clinical benefit to six cycles while reducing treatment burden.

Madison M. Woods, BA; Robert J. Medina, BA; and Carol L. Shields, MD

Surgical Management of Retinal Detachment in Uveal Melanoma

Addressing this complication requires careful planning and follow-up.

Rodrigo Anguita, MBBS, MD, FEBO, FICO, and Lyndon da Cruz, MA, MBBS, PhD, FRCOphth, FRACO

Neoplastic Masqueraders of Uveitis

Remember these various ocular malignancies as you prepare your differential diagnosis.

Ioanna Ploumi, MSc; Konstantina Riri, MD, MSc; and Sofia Androudi, MD, PhD

Does Iris Color Matter in Uveal Melanoma?

Research confirms that light eyes are a risk factor.

Charles DeYoung, BA; Alexandra R. Zaloga, BA; Rolika Bansal, MD; and Carol L. Shields, MD

Tissue Glue-Assisted Plaque Radiotherapy for Uveal Melanoma

A potentially safer approach for eyes with a thin sclera.

Robert J. Medina, BA; Madison M. Woods, BA; Rolika Bansal, MD; and Carol L. Shields, MD

Combination Therapy for Metastatic Uveal Melanoma

A look at the response of large choroidal metastatic melanoma to treatment with darovasertib and crizotinib.

Lauren B. Yeager, MD, and Brian P. Marr, MD

A Masquerade: Leukemia Retinopathy or Viral Infection?

Ocular symptoms thought to be related to malaria turned out to be signs of systemic malignancy.

Brian Wollocko, MD; Samuel Gelnick, MD; and Eric Shrier, DO, FAAO

Ocular Effects of CAR-T Cell Therapy

Know the risks and potential therapeutic benefits associated with this treatment modality.

Lars H. Andersen, MD; Jaskirat S. Takhar, MD; and Jose J. Echegaray, MD

Conditional Survival of Patients With Uveal Melanoma

Factoring in years of metastasis-free survival may lead to an improved prognosis.

Harrison S. Fellheimer, BA; Madison M. Woods, BA; Joseph D. DeSimone, BS; and Carol L. Shields, MD

Ocular Toxicity of New-Age Cancer Therapies

Because modern medications may induce immune-related ocular adverse events, a collaborative approach is important when caring for these patients.

Ronak Shah, BS; Robin A. Vora, MD; Amar Patel, MD; and Ying Qian, MD

Choroidal Melanoma: Does Skin Tone Matter?

The literature shows that Fitzpatrick skin type can affect the prognosis and outcomes of cancers.

Irwin Leventer, BA; Kevin R. Card, BS; and Carol L. Shields, MD

Beware of Congenital Pigmented Ocular Findings

These could indicate overlooked oculodermal melanocytosis, or nevus of Ota, a risk factor for uveal melanoma.

Devon Shatzman, BS; Mrittika Sen, MD; and Carol L. Shields, MD

Intraarterial Chemotherapy for Recurrent Retinoblastoma

An excellent option for primary and secondary therapy.

Rachel S. Kim, BS; Kushal U. Agrawal, MS; and Carol L. Shields, MD

Hemorrhage Over a Choroidal Nevus—Harmless or Hazardous?

Choroidal neovascularization may lead to worrisome findings on fundus autofluorescence, but these do not necessarily indicate malignancy.

Samantha Pastore, BS; Jennifer S. Zeiger, BA; Guy S. Negretti, FRCOphth; and Carol L. Shields, MD

Trilateral Retinoblastoma with Suprasellar Mass

A rare case was effectively treated with high-dose chemotherapy and autologous stem cell rescue.

Catherine K. Liu, BS; Zeynep Bas, MD; and Carol L. Shields, MD

CME Secondary to Extra-Macular Choroidal Melanoma

A rare case of ocular melanoma with retinal invasion leading to remote cystoid macular edema.

Ankur Nahar, BS; Ahmed Sheikh, MD; and Carol L. Shields, MD

The Case of an Iris Melanoma Masquerader

A careful examination is necessary to properly diagnose iridocorneal endothelial syndrome with iris nevus.

Mallory E. Bowers, PhD; Ahmed Sheikh, MD; and Carol L. Shields, MD