Features

IRD Clinical Trial Endpoints: Lessons Learned

Choosing the right outcome measures for inherited retinal disease trials requires matching endpoints to disease biology, therapeutic mechanism, and patient experience.

Melissa Yuan, MD, and Ahmad Al Moujahed, MD, PhD

Genetic Testing in the Retina Practice

What’s changing and why it matters.

Timothy S. Lee, MD; Eric W. Lai, MD; and Sidney A. Schechet, MD

Therapies for IRDs: Moving Beyond Single-Gene Solutions

Emerging gene-agnostic strategies target shared pathways and offer options for IRD patients without mutation-specific therapies.

Aykut Demirkol, MD; Rajvir Solanky; Jayvin Hernandez-Reyes; Ilay Demirkol; and Kuzey Soydas

The Challenge of IRD in Children

Researchers are investigating ways to tackle delayed diagnosis, imaging complications, and unreliable access to genetic testing in pediatric care.

Angela S. Li, MD; Cesar Estrada-Puente, MD; Paula C. Morales, MD; and Ramiro Maldonado, MD

Rare Disease Mystery Cases

Can you diagnose these unusual cases based on the examination and imaging?

Kenneth C. Fan, MD, MBA; Caroline C. Awh, MD; Nimesh A. Patel, MD; Marta Stevanovic, MD, MSc; Maria Emfietzoglou, MD; Demetrios Vavvas, MD, PhD; Mary V. Lang; Lisa A. Schimmenti, MD; Brittni A. Scruggs, MD, PhD; Yicheng Bao, MD; and Hossein Ameri, MD, PhD, FRCSI, MRCOphth

Influence of Mediterranean-Style Diet on AMD

Our findings suggest certain dietary and lifestyle habits may confer long-term protective benefits.

Christopher Phung, BA; Beryl Zhou, BS; Robert Luca, BA; and Dimitra Skondra, MD, PhD

Predicting Progression to GA Using Imaging Biomarkers

Several OCT findings can help clinicians better understand a patient’s risk of progression to sight-threatening disease.

Kelly Donovan, MD, PhD, and Eleonora M. Lad, MD, PhD

PBM for AMD: Mechanisms, Evidence, and Clinical Integration

Photobiomodulation shows promise, but long-term data are needed.

Luis Acabá-Berrocal, MD, and Anton Orlin, MD

Novel MOAs in Wet AMD

The pipeline is full of therapies that hold promise for extending treatment efficacy.

Lejla Vajzovic, MD, FASRS; Robert L. Avery, MD; Carl D. Regillo, MD; and Durga S. Borkar, MD, MMCi

Pearls and Pitfalls of Treating GA and Wet AMD

Concurrent therapy can pose clinical challenges. Here’s how you can manage these patients and maximize outcomes.

Sean D. Adrean, MD, FAAO, and Wesley Han, BS

Landmark Trials in AMD

A summary of the clinical trials that have shaped—and continue to shape—how we treat AMD.

Saghar Bagheri, MD, PHD; Alberto Quarta, MD; Rouzbeh Abbasgholizadeh, MD; Alessandro Feo, MD; Paolo Forte, MD; David Sarraf, MD; Michael S. Ip, MD; and SriniVas R. Sadda, MD, FARVO

Anti-VEGF Step Therapy: An Update

Despite ongoing advocacy efforts, this payer policy persists, putting vision at risk.

Lucas McGuire, BS; Baseer Ahmad, MD; and Jennifer Adeghate, MD, PhD

Widefield OCT: Extending Structural Imaging into the Periphery

These new tools are improving our view.

Alberto Quarta, MD; Ceren Soylu, MD; and SriniVas R. Sadda, MD, FARVO

Imaging Epiretinal Proliferation Using OCT

En face OCT–based identification of proliferative changes may guide surgical strategies in full-thickness macular holes.

Kotaro Tsuboi, MD

Clinical Applications of Microscope-Integrated OCT

Recent advances have improved the utility of intraoperative visualization, with more innovation on the way.

Bani Aguirre, MD, MPH; Anjali Saini, BS; Vahid Ownagh, MD; and Lejla Vajzovic, MD

OR Tech Update: 3D Displays, AI, and Robotics

New visualization tools are expanding what’s possible in the OR.

Kareena Chawla, BS; Jayanth Sridhar, MD; and Prashant D. Tailor, MD

The Value of OCTA in Retinal Vascular Disease

Measuring retinal blood flow is easier than ever before, with new tools under investigation to further improve our ability to assess changes in the retinal vasculature.

Sarah Aman, MD; Viet-Hoan Le, PhD; Ruikang K. Wang, PhD; and Amir H. Kashani, MD, PhD

Parenting and Private Practice: Balance Isn't Everything

Strategies to stay organized, and clinical challenges to address.

Jaya Badhwar Kumar, MD, FASRS

Teleretinal Screening: Closing the Gap in Diabetic Eye Care

Meeting patients where they are—community health centers—can improve screening rates and save vision.

Alice C. Lorch, MD, MPH

How To Increase Diversity on the Podium

Who is presenting matters; it shapes the profession and the aspirations of trainees.

Melissa Yuan, MD; Eugenia C. Greig, MD; and Carolyn K. Pan, MD